Genprex Inc. (NASDAQ: GNPX) Announces Positive Data From Phase 1 Clinical Trial Evaluating REQORSA(R) Immunogene Therapy for Late-Stage Non-Small Cell Lung Cancer

• The positive data from the Acclaim-1 Phase 1 portion of the Phase 1/2 clinical trial has been published in an abstract at the 2023 American Society of Clinical Oncology Annual Meeting, which took place in Chicago, IL and online June 2 – 6, 2023
• Acclaim-1 is an open-label, multi-center Phase 1/2 clinical trial evaluating REQORSA(R) in combination with Tagrisso(R)
• The Phase 2 expansion portion of the study is expected to enroll approximately 66 patients – half of which will have only received Tagrisso(R) and the other half receiving Tagrisso(R) and chemotherapy
• The global lung cancer treatment market is expected to grow to $48.7 billion by 2026

Genprex (NASDAQ: GNPX), a clinical-stage gene therapy company focused on developing life-changing therapies for patients with cancer and diabetes, recently announced that positive data from the Phase 1 portion of its Acclaim-1 clinical trial evaluating REQORSA(R) Immunogene Therapy in combination with Tagrisso(R) in late-stage non-small cell lung cancer (“NSCLC”) have been published in an abstract at the 2023 American Society of Clinical Oncology (“ASCO”) Annual Meeting, which took place June 2-6, 2023 at McCormick Place in Chicago, IL, and online (https://nnw.fm/aSisq). 

The preliminary results from eight patients show that the combination of REQORSA and Tagrisso was well tolerated at all three dose levels of the Phase 1 trial, with encouraging evidence of efficacy observed. “We are thrilled to have our abstract, which reports positive results from the Phase 1 portion of our Acclaim-1 clinical trial, published at the ASCO Annual meeting,” said Mark Berger, MD, Chief Medical Officer at Genprex. “We are encouraged by the favorable safety profile of REQORSA, as well as the preliminary efficacy data we have observed.  These data supported the Safety Review Committee’s approval of our advancement to the Phase 2 expansion portion of the clinical trial, which we expect to begin in the third quarter.”

The Acclaim-1 clinical trial is an open-label, multi-center Phase 1/2 clinical trial evaluating the company’s lead drug candidate in combination with Tagrisso in patients with late-stage NSCLC with activating epidermal growth factor receptor mutations whose disease progressed after treatment with Tagrisso. The dose escalation Phase 1 portion of the Acclaim-1 clinical trial has been completed, and the Phase 2 expansion portion of the study is expected to enroll approximately 66 patients, half of whom will have received only Tagrisso treatment – the other half will have received Tagrisso and chemotherapy treatments.

Genprex works with world-class institutions and collaborators to develop drug candidates to further its pipeline of gene therapies to provide novel treatment approaches, which includes its lead product candidate REQORSA Immunogene Therapy. REQORSA consists of the TUSC2 gene expressing plasmid encapsulated in non-viral nanoparticles made from lipid molecules with a positive electrical charge. The drug candidate is injected intravenously and targets cancer cells.

Developing resistance to drugs like Tagrisso, Keytruda, and Tecentriq is inevitable for many cancer patients. In addition, the average five-year lung cancer survival rate is 18.6%, which highlights the importance of REQORSA’s potential in the global lung cancer industry, which is expected to grow to $48.7 billion by 2026 (https://nnw.fm/X7KmN).

“It is encouraging that several patients whose disease was progressing on their previous therapy are now having long periods of response and stable disease in the Phase 1 portion of the study,:” said Rodney Varner, Chairman, President, and Chief Executive Officer of Genprex. “We wish to thank the patients and investigators participating in our clinical trials and our investors who make it possible to move our drug candidates forward toward regulatory approval for patients in need.”

For more information, visit the company’s website at www.Genprex.com.

NOTE TO INVESTORS: The latest news and updates relating to GNPX are available in the company’s newsroom at http://nnw.fm/GNPX

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Electronic Servitor Publication Network Inc. (XESP) Transforms B2B Companies with “Growth as a Service”

 

• XESP’s proprietary Digital Engagement Engine(TM) develops real connections with target markets, pointing to the future of growth for B2B organizations
• The Digital Engagement Engine(TM) is a sophisticated technology stack that does 1-to-1 contact analysis and 1-to-1 content provisioning making sure that the right audience is reached and that interactions are productive
• XESP’s offering is called “Growth as a Service” which provides fully managed digital services focused on enhancing growth for B2Bs

The digital landscape has transformed and evolved over the past few years – going from a focus primarily on SEO, to social media, content, and video marketing campaigns. Now, there are thousands of tactics being thrown on the drawing table being pushed by the latest digital marketing gurus – but none of these omnichannel marketing schemes are as effective as Electronic Servitor Publication Network (OTCQB: XESP) Digital Engagement Engine(TM). Not to be considered just a marketing tool, it’s a powerful new way to ensure real connections between clients and their target markets, and it represents the future of business growth.

XESP is a market disruptor for B2B companies, utilizing cutting-edge data analytics and smart technology to identify the needs within a given target market. The company can then tailor content to meet that market’s precise needs and deliver it to them exactly when needed. The company has coined this managed service as “Growth as a Service.”

Data is run through XESP’s Digital Engagement Engine(TM), which is a sophisticated technology stack that does 1-to-1 contact analysis and 1-to-1 content provisioning, making sure that communications are relevant, meaningful, and create a positive experience. XESP’s technology goes beyond omnichannel marketing, offering a way for those who want to reach their target markets right where they are, and create meaningful engagements that stay with them until they become valued customers.

XESP’s highly focused approach includes the following:

• Cutting-edge Data Analysis – smart tools and techniques to flawlessly acquire data
• Identification Tech Stack – identification of communities of interest within a target market
• Tailored Content – designed to attract and engage individuals within that target market
• Precision Delivery – drive customers to action by addressing their needs at the optimal moment…when they need it

XESP’s focus is to enhance growth through the effective application of technology and service for B2B organizations that are looking for a minimum of $10 million in additional growth. XESP’s managed service utilizes its technology to help businesses increase their presence in a way that surpasses the traditional omnichannel approach.

For more information, visit the company’s website at www.XESPN.com. 

NOTE TO INVESTORS: The latest news and updates relating to XESP are available in the company’s newsroom at https://nnw.fm/XESP

About NetworkNewsWire

NetworkNewsWire (“NNW”) is a financial news and content distribution company, one of 50+ brands within the InvestorBrandNetwork (“IBN”), that provides: (1) access to a network of wire solutions via InvestorWire to reach all target markets, industries and demographics in the most effective manner possible; (2) article and editorial syndication to 5,000+ news outlets; (3) enhanced press release solutions to ensure maximum impact; (4) social media distribution via IBN to millions of social media followers; and (5) a full array of corporate communications solutions. As a multifaceted organization with an extensive team of contributing journalists and writers, NNW is uniquely positioned to best serve private and public companies that desire to reach a wide audience comprising investors, consumers, journalists and the general public. By cutting through the overload of information in today’s market, NNW brings its clients unparalleled visibility, recognition and brand awareness. NNW is where news, content and information converge.

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2023 Reg A Conference Welcomes Investors, Companies Seeking Alternative Capital Raises

 Companies looking for alternative methods of raising capital and investors interested in overlooked breakout opportunities will find the annual Reg A Conference, hosted by DealFlow Events, an exciting event to conduct business and learn about the current market.

This year’s Reg A Conference will take place June 30 in New York’s luxurious Westchester Country Club, just a few minutes north of New York City.

This one-day gathering provides insight on marketing strategies, a review of the current capital-raise landscape, news about regulatory oversight and analysis of what has (and hasn’t) worked in recent Reg A transactions.

Our agenda for The Reg A Conference is now available at https://regaconference.com/agenda/. Besides panels and presentations from thought leaders such as Jonathan Stidd of DealMaker Reach, Nathaniel Dodson of Crowdfunding Lawyers, Dawson Russell of Capital Raise, Irene Hyder of One9 Strategy, and more, The Reg A Conference is known for giving attendees a networking experience they won’t find anywhere else.

New to this year’s conference is a dedicated space for scheduled one-on-one meetings between qualified companies and attendees looking for investment opportunities, banking relationships, or professional services. Prior to the event, all attendees will receive a program guide with tear sheets containing companies’ financial data and background information, enabling participants to set up 20-minute meetings with the companies of their choice using intuitive MeetMax software.

Throughout the day, the relaxed, open-air atmosphere of the Westchester Country Club will keep attendees refreshed and relaxed, so they are ready to seize the educational and networking opportunities this popular event has to offer.

Best of all, the whole experience is FREE to private and public companies considering or in the process of conducting Reg A transactions. If you plan on attending the event as an executive-level employee of a qualifying private or public company, visit https://regaconference.com/private-companies/ to receive your free ticket.

Things to know:

• Situated on New York’s eastern seaboard, proximate to New York City’s international financial capital
• Panelists and presenters focused exclusively on alternative financing for the Reg A marketplace; no fluff, no filler, just actionable information
• Insights on how Reg A works, timelines, fees, regulations and real-life activity
• Networking opportunities in one of the most prestigious country clubs in America, amid a relaxed atmosphere and space designed to facilitate the free flowing exchange of information
• Invited professionals including underwriter and issuer law firms, structured financial investors and Reg A investors, investor relations professionals, accountants, marketing consultants and fund managers
• One-on-one dedicated scheduling as a new feature to this annual event, powered by MeetMax software and company data statements

Behind the scenes:

DealFlow Events has hosted more than 200 events covering a range of financial topics during the last 20 years. Seasoned conference developers bring leading practitioners in each field together with major sponsors that service the respective markets.

DealFlow’s events take place in-person and virtually to provide access to all individuals working within their industries. The conference series has extended to international arenas, taking place in the United States, Europe, Asia, the Middle East, and Canada.

For more information about this event and to register, please visit https://nnw.fm/jwjrb.

About NetworkNewsWire

NetworkNewsWire (“NNW”) is a financial news and content distribution company, one of 50+ brands within the InvestorBrandNetwork (“IBN”), that provides: (1) access to a network of wire solutions via InvestorWire to reach all target markets, industries and demographics in the most effective manner possible; (2) article and editorial syndication to 5,000+ news outlets; (3) enhanced press release solutions to ensure maximum impact; (4) social media distribution via IBN to millions of social media followers; and (5) a full array of corporate communications solutions. As a multifaceted organization with an extensive team of contributing journalists and writers, NNW is uniquely positioned to best serve private and public companies that desire to reach a wide audience comprising investors, consumers, journalists and the general public. By cutting through the overload of information in today’s market, NNW brings its clients unparalleled visibility, recognition and brand awareness. NNW is where news, content and information converge.

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Ucore Rare Metals Inc. (TSX.V: UCU) (OTCQX: UURAF) Finalizes Department of Defense $4 Million Agreement for Demonstrating Critical REE Solution

 

• Canada-based Ucore Rare Metals Inc. is devoted to establishing a North American-based supply chain for rare earth elements to reduce the Western hemisphere’s dependence on China’s market-dominant industries for modern technologies
• The company has developed a trademarked process for separating rare earths from their surrounding ores 
• Ucore is preparing to begin construction of a commercially scalable facility in Louisiana for using its solution
• The U.S. Department of Defense awarded the company $4 million in an agreement this month that calls on Ucore to demonstrate the capabilities of its technology and the company’s ability to use it for sustaining North American REE production
• The agreement’s parameters are established in stages with payment tranches set for the successful completion of each stage
• Successful completion of the agreement’s requirements could lead to follow-on award opportunities for Ucore to continue its work

Critical metals production innovator Ucore Rare Metals (TSX.V: UCU) (OTCQX: UURAF) received a significant boost to its new technology demonstration pipeline this month when the the U.S. Department of Defense awarded the Canadian company $4 million to respond to the DOD’s inquiries into its RapidSX(TM) rare earths separation process (https://nnw.fm/euPKS).

Ucore is promoting RapidSX(TM) as a faster and more environmentally sound upgrade to the solvent extraction method (SX or CSX) that has been the standard for separating rare earths (“REEs”) for more than four decades. The company has been demonstrating the capabilities of its technology at a 52-stage Demo Plant in Ontario during the spring as it prepares to launch commercial production in Louisiana.

The DOD’s interest in RapidSX(TM) arises from Western nations’ concerns about China’s dominance of CSX production industries, particularly amid international tensions between the United States and China over modern technologies production, alleged state-sponsored industrial spying, China’s new militarization and its use of its rare earths trading power to wield control over its disputes with other nations.

“Independent testing has shown that the innovative column-based RapidSX platform can separate rare earths nearly 10 times faster within a footprint that is about one-third the size required for the mixer-settler units used for traditional SX separation,” Alaska’s Metal Tech News noted (https://nnw.fm/Uk0zo).

Rare earths are vital to many modern computerized application processes, particularly because of their use in high-performance magnets. Although they are referred to as “rare,” they exist in plentiful numbers worldwide. But because they constitute a small portion of the ores they are found in, efforts to extract them at scale require significant process development. 

The modern computerized applications not only support commercial industries, but also military defense needs.

Las Vegas-based MP Materials’ Mountain Pass mine located in Southern California currently is the only source for REE feedstock in North America, and its ore is processed in China, reflecting the state of the market since China began pumping out low-cost REEs in the 1980s, leading North American REE mines to shutter their operations (https://nnw.fm/GADm3).

“When it comes to clean energy, China has spent years cornering the market on many of the materials that power the technologies that we rely on,” President Joe Biden said in February (https://nnw.fm/b7Fom). “We can’t build a future that’s made in America if we ourselves are dependent on China for the materials that power the products of today and tomorrow. And this is not anti-China or anti anything else; it’s pro-American.”

The DOD award agreement requires Ucore to show that its technology constitutes new innovation capable of supporting North American REE production plants, and that it can commercially convert heavy and light REE feedstock sources to salable individual rare earth products at its soon-to-be-constructed processing facilities, known as Strategic Metals Complexes (“SMCs”), the first of which will begin construction this year in Alexandria, La.

The June 2 agreement establishes stages for demonstrating RapidSX(TM) capabilities with regular reporting to the U.S. Army Contracting Command-Orlando, and payment in tranches that are dependent on the successful completion of each stage.

For more information, visit the company’s website at www.Ucore.com.

NOTE TO INVESTORS: The latest news and updates relating to UURAF are available in the company’s newsroom at https://nnw.fm/UURAF

About NetworkNewsWire

NetworkNewsWire (“NNW”) is a financial news and content distribution company, one of 50+ brands within the InvestorBrandNetwork (“IBN”), that provides: (1) access to a network of wire solutions via InvestorWire to reach all target markets, industries and demographics in the most effective manner possible; (2) article and editorial syndication to 5,000+ news outlets; (3) enhanced press release solutions to ensure maximum impact; (4) social media distribution via IBN to millions of social media followers; and (5) a full array of corporate communications solutions. As a multifaceted organization with an extensive team of contributing journalists and writers, NNW is uniquely positioned to best serve private and public companies that desire to reach a wide audience comprising investors, consumers, journalists and the general public. By cutting through the overload of information in today’s market, NNW brings its clients unparalleled visibility, recognition and brand awareness. NNW is where news, content and information converge.

To receive SMS text alerts from NetworkNewsWire, text “STOCKS” to 77948 (U.S. Mobile Phones Only)

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